OC-087 PAIN AND INFLAMMATORY SIGNALLING IN TACKOMESH TRIAL PARTICIPANTS FOLLOWING ELECTIVE LAPAROSCOPIC INCISIONAL HERNIA REPAIR WITH INTRAPERITONEAL ONLAY MESH (IPOM) AND SPIRAL-TACK MESH FIXATION
نویسندگان
چکیده
Abstract Background The aim of this study was to investigate for links between reported pain and inflammation within a sub-cohort patients undergoing the IPOM plus repair through measurement serum/plasma levels established inflammatory biomarkers in trial participants across 1-year follow up. Methods 22 (12 Protack™ 10 Reliatack™) TACKoMesh randomised controlled underwent serial blood sampling as part their A panel pro- anti-inflammatory were assayed using Luminex multiplex assays ELISAs. Circulating biomarker concentrations described compared context clinical patient outcome data that obtained trial. Results An increase serum concentration (IL-6 CRP) anti- (IL-10) seen following repair. Serum IL-6 CRP significantly raised baseline at post-operative Days 1, 6 30 (p < 0.05). Markers onward signalling (Cortisol TNF-alpha) tissue (PDGF-AA VEGF) showed trend towards an elevation similar timepoints (notably post-op Day 6) but not different from levels. There no observed correlations signal pain, treatment allocation trial, burden implanted prosthetic material, or hernia recurrence. Discussion This demonstrates novel finding pro-inflammatory
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2022
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znac308.097